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"Characterization of lymphatic fluid circulating vesicles as novel
biomarkers of metastasis"
Principal Investigator: Dr. Hector Peinado Selgas
Institution: Weill Medical College of Cornell University
Metastasis is the most devastating phase of tumor progression in all cancers as
commonly observed in melanoma. In our laboratory we are analysing the role of
small vesicles secreted by the tumor (called exosomes) in tumor progression and
metastasis. Our data suggest that tumor-derived exosomes can circulate in the
lymphatic fluid reinforcing tumor metastasis. While blood samples are routinely
analysed, lymphatic fluid has been greatly overlooked for its potential for novel
biomarkers in cancer progression. We propose use lymphatic fluid circulating
exosomes as novel biomarkers of melanoma progression. Our studies in cancer
patients will be the first analysing new markers in negative sentinel lymph nodes
to predict recurrent disease and metastasis. The goal of the current project is
to determine the composition of the lymphatic fluid vesicles and develop new
markers to predict and block metastasis.
The above project description is supplied by the Principal Investigator