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Prior Funding
Copyright 2008-2013 - Feldstein Medical Foundation, Inc.
PRIOR FUNDING
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"Distinct contributions of human monocyte subsets to antifungal
defense"
Principal Investigator: Dr. Amariliz Rivera
Institution: Rutgers - NJMS

Fungal pathogens are increasingly recognized as a significant problem of global
concern. The threat of fungal infections to human health has steadily risen over
the past several decades yet our understanding of relevant mechanisms of host
protection lags behind our knowledge of infections with other microorganisms
like bacteria and viruses. The goal of our studies is to fill this gap in knowledge
by examining how the host immune system fights fungal infections. In our
ongoing studies with animal models of fungal disease we have uncovered that a
specific subset of immune cells (Inflammatory monocytes) are essential in
defense against fungal infection. In the studies funded by the Feldstein Medical
Foundation we will examine whether our findings in animals translate to human
immune cell subsets. We will specifically examine the responses of human
monocyte subsets to fungal infection and dissect potential mechanisms of
monocyte-mediated defense against fungi. The long-term goal of our studies is
to use this knowledge as a foundation for developing new therapies that
harness the immune system to control fungal infections.
The above project description is supplied by the Principal Investigator