Grant Application
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"Gut microbiota, metabolites and diabetes in HIV infection"
Principal Investigator: Dr. Qibin Qi
Institution: Albert Einstein College of Medicine

Excess risk of chronic cardiometabolic diseases has become a major
concern in people living with HIV, yet an understanding of its
pathophysiology remains incomplete. Emerging evidence suggests that
gut microbiota and related metabolites are involved in host metabolic
disturbances and may play a role in the development of cardiometabolic
diseases (e.g., diabetes), but few studies have been conducted among
individuals with HIV infection. In this project, we propose to perform gut
microbiome test on fecal samples and conduct metabolite assay on
specimens (e.g., blood, urine) from HIV-infected women from the
Women's Interagency HIV Study, an ongoing prospective HIV cohort. We
aim to investigate the role of gut microbiota in the development of
diabetes during HIV infection and explore potential mechanisms by
examine functional metabolites. Our study focusing on gut microbiota
and related metabolites has the potential to uncover novel risk factors
for diabetes and may provide new insights into the pathophysiology of
diabetes among HIV-infected individuals, enabling early intervention and
monitoring. This would be a unique confluence of information which is
novel not just in HIV infection research but cutting edge in the diabetes
and cardiovascular field.

The above project description is supplied by the Principal Investigator