Grant Application
About Us
Prior Funding
"Three-dimensional correlated electrical conduction and tissue
Principal Investigator: Dr. Christine Hendon
Institution: Columbia University Medical Center

At early stages of some diseases, healthy cardiac muscle is progressively
replaced by fat or scar tissue. Early detection of this process will help to
identify patients at risk of sudden cardiac death and may serve as an indication
for therapy for the treatment of abnormal electrical rhythms of the heart,
arrhythmias. Early detection requires cellular level imaging, which is
approximately 100 x 10 um. Cardiac arrhythmias afflict millions of patients in the
United States, where standard methods to treat cardiac arrhythmias include
radiofrequency ablation therapy, which is guided by one or two-dimensional
electrical measurements to determine where to deliver treatment. A better
understanding how the microstructure of the cardiac muscle influences
electrical conduction will greatly inform these therapeutic procedures. My goal
is to develop high-resolution optical imaging technologies that can correlate
tissue microstructure to electrical function, for improved guidance of
radiofrequency ablation therapy. I aim to show that high-resolution imaging
provided by optical coherence tomography can provide tissue characterization
and information regarding the orientation and disarray of muscle cells, which will
allow for patient specific models of electrical conduction.
Copyright 2008-2015 - Feldstein Medical Foundation, Inc.
For questions or comments regarding this web site please contact the webmaster
855 Valley Road, Third Floor, Clifton, NJ 07013
The above project description is supplied by the Principal Investigator