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"Curcumin Nanoparticles as an Innovative, Multi-mechanistic
Antimicrobial and Wound Healing Accelerant"
Principal Investigator: Dr. Adam Friedman
Institution: Albert Einstein College of Medicine of Yeshiva University
Community and hospital-acquired infections caused by multidrug-resistant
(MDR) pathogens are rising at an alarming rate. Microbial antibiotic resistance
has developed as a result of both the inherent resistance in some organisms
and the ease with which they can acquire and transfer antibiotic-resistant
strategies from one another. Abuse in the use of broad-spectrum antibiotics has
further spurred the emergence of many antibiotic-resistant strains. In this
regard, resistance to antibiotics has become a public health threat of epidemic
proportions resulting in increased mortality and morbidity, therefore, highlighting
the need for innovative approaches in the development of antimicrobial agents.
Curcumin is a naturally derived substance with innate antimicrobial and wound
healing properties. Acting by multiple mechanisms, curcumin is less likely than
current antibiotics to select for resistant bacteria. Curcumin's poor water
solubility and rapid degradation profile hinder usage; nanoparticle encapsulation
overcomes this pitfall and enables extended delivery of curcumin. Using a unique
nanoparticle platform, we are developing new ways to effectively deliver this
highly relevant natural compound for the treatment of infected wound.
Curcumin nanoparticles may represent a novel topical antimicrobial and wound
healing adjuvant for infected burn wounds and other cutaneous injuries.
The above project description is supplied by the Principal Investigator